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Split hand sign is a classic clinical sign seen in Motor Neuron Disease (MND), especially Amyotrophic Lateral Sclerosis (ALS). 🔍 What is it? It refers to selective wasting and weakness of: Thenar muscles (Abductor Pollicis Brevis) First dorsal interosseous (FDI) With relative sparing of: Hypothenar muscles (especially Abductor Digiti Minimi) ➡️ This creates the appearance of the hand being “split” into wasted and preserved muscle groups. ✋ Muscles Involved Wasted Spared Thenar muscles Hypothena

Nick Pappas, MD on Instagram: "Split hand syndrome can be one of the early signs of ALS (amyotrophic lateral sclerosis), the progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. As motor neurons deteriorate and die, they can no longer send signals to the muscles, leading to muscle weakness, atrophy, and eventual paralysis. 🚨 Other early signs of ALS can be tongue fasciculations (muscle twitching), difficulty swallowing, or weakness in a particular limb.