Update on SORL1: Trafficking is Paramount, in Neurons and …
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · The microglia then use a cell-specific ATP/ADP hydrolyzing ectoenzyme called CD39 to convert the ATP into AMP, which is then hydrolyzed to adenosine via CD73 receptors …
Moving Target: New Biology Casts TREM2 as a Shifty Mark
Apr 17, 2025 · For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation by TREM2 agonist antibodies. This …
Lipid-Laden, Sluggish Microglia? Blame Aβ. - ALZFORUM
Sep 6, 2023 · Microglia and macrophages make lipid droplets when stressed by inflammation. Scientists believe the lipids sustain the cells’ metabolic need, enabling them to respond to …
Inhaled xenon modulates microglia and ameliorates disease in …
Jan 18, 2025 · This is an interesting paper that explores the impact of xenon therapy on microglia trajectories in different transgenic models with different disease-associated pathologies. The …
Microglia Build Plaques to Protect the Brain - ALZFORUM
Apr 22, 2021 · Could it be that microglia build plaques rather than bust them? In the April 15 Nature Immunology, researchers led by Greg Lemke at the Salk Institute for Biological …
VHB937 | ALZFORUM
Jun 6, 2025 · VHB937 is a humanized monoclonal antibody to the immune receptor TREM2. TREM2 activation stimulates proliferation and phagocytic function of microglia, which play a …
Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · PU.1-low microglia were rare, making up less than 1 percent of the total. To a “T.” A subtype of regulatory microglia express many of the immunomodulatory receptors typically …
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, …
Oct 30, 2024 · The scientists next explored how lysosomal function influenced the development of ApoE aggregates within microglia. Both in a cultured microglial cell line and in human iPSC …
Part with PILRA, Power Up Microglia? - ALZFORUM
Jul 19, 2024 · Unlike wild-type microglia, PILRA-less iMG barely changed gene expression in response to interferon-γ or lipopolysaccharide (LPS), suggesting they tone down their …