Aberrant DNA methylation patterns are a characteristic feature of cancer including myeloid malignancies such as acute myeloid leukemia (AML). The mechanisms behind aberrant DNA methylation have ...

Methylation is any chemical reaction that adds a methyl chemical group (CH3, sometimes abbreviated in chemical structures as Me). In biology, it is a post-translational modification that occurs on ...

Top of the list is PRMT5/MTA inhibitor MRTX1719, which BMS said could be a first-in-class therapy for cancers with MTAP deletions seen in around 10% of all cancers, including NSCLC, as well as ...

TNG456 is a next-generation, brain-penetrant, MTA-cooperative PRMT5 inhibitor. “Dosing the first patient in the TNG456 Phase 1/2 trial mark Tango Therapeutics, Inc. ( NASDAQ:TNGX ) missed ...

The cuts are "in light of the extremely challenging financial markets" and the biotech's "strong conviction in the value of our clinical programs," which include two PRMT5 inhibitor cancer candidates.

Following after is P-500, a selective, brain-penetrant PRMT5 inhibitor for advanced solid tumours, including high-grade glioma and uveal melanoma, that Pathos AI acquired from Prelude Therapeutics ...

Protein arginine methylation is an epigenetic modification function not only in transcription, RNA processing, and signal transduction cascades, but also in many cancer-immunity cycle processes.