Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

A hidden clue may explain why some mutated cells become cancerous and others don’t: how fast they divide. A new study from ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

The work shows that the AGO2 protein follows the tumor suppressor p53 into the nucleus, binding itself to genes that regulate the body's alarm signals and turning them off. The researchers also ...

Loss of the tumor suppressor p53 facilitates the malignant progression of colorectal cancer (CRC) following the initial transformation. Here, the authors report that p53 protein degradation ...

or the corresponding wild-type codon (CGA), along with four upstream and three downstream flanking codons of human p53 coding sequence, were inserted into the open reading frame of Renilla luciferase ...

Nishanth Thalambedu, Nadia Safar, Ahmad Mazin M. Safar. Mining the Kras-p53 mutational interface for synthetic lethality (SL) in pancreatic adenocarcinoma (PA) [abstract]. In: Proceedings of the ...

p53 is a tumor suppressor protein with multiple isoforms with shared or ... in binding to p53-regulated promoters and inducing expression of the p53 target genes. Moreover, the Δ133p53 and Δ160p53 ...