Scientists have recently shed some light on exactly why elephants, one of the biggest animals on the planet, paradoxically ...

Discoveries announced today by St. Jude Children's Research Hospital provide a scientific rationale for the targeted ...

May 15, 2025) Discoveries announced today by St. Jude Children's Research Hospital provide a scientific rationale for the targeted ...

Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

1Gastrointestinal Cancers, Beijing Key Laboratory of Cell & Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of GI Oncology ...

This enzyme travels along DNA and uses methylation to mark which genes should be expressed ... and repairing this DNA damage is the p53 tumor-suppressor pathway. "We found that the p53 tumor ...

This enzyme travels along DNA and uses methylation to mark which genes should be ... this DNA damage is the p53 tumour-suppressor pathway. "We found that the p53 tumor-suppressor signalling ...

Following γ-irradiation, Dnmt3a R878H/+ mice show accelerated development of thymic T-cell lymphomas. γ-irradiated pre-leukaemic Dnmt3a R878H/+ LSK cells show subtle downregulation of p53 signalling ...

Department of Infectious Diseases and Hepatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, P. R. China Institute for Stem Cell & Regenerative Medicine, The Second ...

The work shows that the AGO2 protein follows the tumor suppressor p53 into the nucleus, binding itself to genes that regulate the body's alarm signals and turning them off. The researchers also ...