Scientists have recently shed some light on exactly why elephants, one of the biggest animals on the planet, paradoxically ...

Discoveries announced today by St. Jude Children's Research Hospital provide a scientific rationale for the targeted ...

Once researchers redefined p53 as a tumor suppressor gene and generated nonmutated clones, they began piecing together the puzzle of its role in the cell. One group showed that p53 controlled the ...

A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its ...

May 15, 2025) Discoveries announced today by St. Jude Children's Research Hospital provide a scientific rationale for the targeted ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Work at Scorpion Therapeutics Inc. has led to the identification of cellular tumor antigen p53 (TP53) (Y220C mutant) activators reported to be useful for the treatment of cancer.

Colorectal cancer is the second leading cause of cancer-related death globally. Although some of the molecular changes ...

Animation still showing the p53 tumour suppressor (yellow) protein binding to DNA (magenta/beige). p53 is a critical protein that determines how cells respond to DNA damage. Disclaimer ...

This enzyme travels along DNA and uses methylation to mark which genes should be expressed ... and repairing this DNA damage is the p53 tumor-suppressor pathway. "We found that the p53 tumor ...

This enzyme travels along DNA and uses methylation to mark which genes should be ... this DNA damage is the p53 tumour-suppressor pathway. "We found that the p53 tumor-suppressor signalling ...