For many years, the most common drug used to treat gout was allopurinol, which is generally safe and effective, but has been known to cause life-threatening rashes in rare cases. Its dosage often ...

Allopurinol hypersensitivity syndrome (AHS) is characterized by severe rash, fever ... Fifty-four patients treated for gout with allopurinol and who developed AHS were identified.

In the first 6 months of allopurinol therapy, gout flare risk was significantly linked to flare in the month prior and a 100 mg starting dose. Some patients may require longer prophylaxis duration.