Pore-forming proteins in living cells, termed ion channels, are embedded in the outer membrane of almost all cell types and ...

The QT interval was now normal; however, there were persistent T-wave inversions in leads I, aVL and V4–6. Flecainide blocks sodium channels in cardiomyocytes. Intoxication with flecainide is rare, ...

Competing Interests: The author declared no competing interests. Voltage-gated sodium channels can contribute to axonal injury in multiple sclerosis (MS) by providing a pathway for sustained ...

New York, USA, April 09, 2025 (GLOBE NEWSWIRE) -- Sodium Channel Blockers Clinical Trial Pipeline Accelerates as 20+ Pharma Companies Rigorously Developing Drugs for Market Entry | DelveInsight ...

a sodium channel protein essential for inducing the action potential (AP) that initiates cardiomyocyte contraction. Current Nav1.5 blockers, including Class I antiarrhythmic drugs like Flecainide, ...

The research of South San Francisco-based SiteOne focuses on sodium channels, which are membrane proteins that transmit electrical signals. Just as a building has wiring throughout its structure ...

Flecainide acetate is a Class 1c anti-arrhythmic with a potent sodium voltage gated channel blockade which is utilized for the second-line treatment of tachyarrhythmias in children and adults. Given ...

PHILADELPHIA -- An oral, non-addictive sodium channel blocker safely relieved moderate-to-severe acute pain following surgery, according to phase III data that could support regulatory approval.

This group includes flecainide (Tambocor) and propafenone (Rhythmol). These medications are effective for many types of arrhythmias because they effectively block sodium channels. However ...

SVT Sodium channel blockers such as flecainide; potassium channel blockers such as Pacerone (amiodarone) and Betapace (sotalol) Antiarrhythmic drugs treat abnormal heart rhythms (arrhythmias) by ...

When sodium enters the cell via these channels, a pump calledNKA increases its activity to eject it, like bailing water out of a ship. This uses a lot of energy, which the cell provides through ...

A study on live tissue cells is the first to reveal how channels that allow sodium to enter into breast cancer cells enable tumors to grow and spread. The discovery adds to evidence which suggests ...