From the Department of Medicine, University of Chicago. Supported in part by a grant (AM-07091) from the United States Public Health Service. † Assistant professor of medicine, Department of ...

The metabolism of bilirubin begins with its production from heme in the spleen and bone marrow, followed by transportation to the liver, where it undergoes enzymatic conversion. The liver plays a ...

Conjugation of bilirubin and delivery to the intestine doesn't necessarily lead to excretion of the substance. Neonatal intestines contain beta-glucuronidase, an enzyme capable of reducing ...

The rate of progression of clinical signs depends on rate of bilirubin rise, duration of hyperbilirubinemia, host-susceptibility, and presence of co-morbidities. Death from acute kernicterus is ...

Biliverdin IXβ reductase (BVR-B) catalyzes the pyridine nucleotide-dependent production of bilirubin-IXβ, the major heme catabolite during early fetal development. BVR-B displays a preference ...

IN the development of new methods for detecting bilirubin in urine technical simplicity has generally been sacrificed for increased sensitivity and specificity. As a consequence many clinicians ...