Although mutations in the SWI/SNF remodeler subfamily are known to be linked to over 20% of all human cancers, how these mutations disrupt their interactions with DNA to ultimately lead to cancer ...

In eukaryotes, DNA is tightly wound into a complex called chromatin. Thanks to the process ... Recent evidence from the SWI/SNF and ISWI remodeler families has also revealed that remodeler ATPases ...

When genes are coiled and compacted into chromatin, they're no longer accessible to transcription factors. So how does the cell know where to uncoil in a process called chromatin remodeling?

SMARCA4 and SMARCA2 are essential subunits of the SWI/SNF complex, functioning as ATP-dependent chromatin remodelers that regulate gene expression and maintain cellular homeostasis. Recent research ...