The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

In the classic view of the transcriptome, RNA polymerase initiates transcription ... For eukaryotic Pol II, 'correct' initiation events lead to discrete RNA species, most of which are messenger ...

This polymerase contains four catalytic subunits ... RNA pol I transcribes ribosomal RNAs (rRNAs), RNA pol II transcribes RNAs that will become messenger RNAs (mRNAs) and also small regulatory ...

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...

“Instead, we discovered that these phosphorylation sites work together but have distinct and opposing effects on RNA polymerase II elongation speed and the output of RNA.” The study used a ...

Like mRNA, the majority of lncRNAs are polyadenylated and transcribed by RNA polymerase II. Loci that produce lncRNAs have many features similar to protein-coding genes, promoters, alternative ...

Northwestern Medicine scientists have uncovered how a testis-specific protein contributes to tumor growth and progression in ...

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

The Mediator complex is a system that regulates protein-coding gene transcription, where mediator of RNA polymerase II transcription subunit 16 (MED16) is a subunit belonging to this system.