This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Northwestern Medicine scientists have uncovered how a testis-specific protein contributes to tumor growth and progression in lung cancer, according to a study published in Science Advances.

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

miRNAs are encoded in our genome and are generally transcribed by RNA polymerase II. Despite the growing evidence for their importance in normal physiology, little is known about the regulation of ...

Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells, Cell (2019). Guanshi Wang, Jesse Hauver, Zachary Thomas, Seth A. Darst, Alexandros Pertsinidis.

Stanford Medicine researchers have developed a blood test capable of detecting cancers, the ways cancer resists treatments ...

When RNA molecules are synthesized by cells — a critical process in the creation of proteins and other cellular functions — they typically undergo a series of “folding” events that determine their ...