There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

In the classic view of the transcriptome, RNA polymerase initiates transcription ... For eukaryotic Pol II, 'correct' initiation events lead to discrete RNA species, most of which are messenger ...

This polymerase contains four catalytic subunits ... RNA pol I transcribes ribosomal RNAs (rRNAs), RNA pol II transcribes RNAs that will become messenger RNAs (mRNAs) and also small regulatory ...

“Instead, we discovered that these phosphorylation sites work together but have distinct and opposing effects on RNA polymerase II elongation speed and the output of RNA.” The study used a ...

Like mRNA, the majority of lncRNAs are polyadenylated and transcribed by RNA polymerase II. Loci that produce lncRNAs have many features similar to protein-coding genes, promoters, alternative ...

The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, Mediator, and RNA polymerase II (pol II). As a central integrator of both general and TF-specific regulatory signals, Mediator plays a ...

The Mediator complex is a system that regulates protein-coding gene transcription, where mediator of RNA polymerase II transcription subunit 16 (MED16) is a subunit belonging to this system.

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...

This enables the RNA polymerase (RNAP) and the ribosome to coordinate their functions and work together efficiently directly.