p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with polymorphisms ...

Figure 1: Schematic representation of the configurations assumed by oligonucleotides with an overlap complementary to a DNA target. To characterize the structural requirements for cleavage by the FEN1 ...

Forget the hero-worship of famous logo designers. The real lesson isn't about their art but their ruthless ability to solve commercial problems. We celebrate the simple mark but ignore the strategic ...