If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...

aDepartment of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, United States bDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, United ...

confirming the reduction of both NF-κB methylation and its subsequent activation upon drug treatment. These findings provide compelling grounds for considering Can and Clo as anti-PRMT5 cancer ...

Many interesting questions remain. It will be important to investigate how looping affects gene expression and whether Prmt5-dependent histone arginine methylation is a contributing factor. It will ...

Here, we correlated nuclear PRMT5 expression with sensitivity to Tam in two independent cohorts of ERα + BC cells, and demonstrated that nuclear ERα methylation by PRMT5 is an important step in the ...

Protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes symmetric and asymmetric methylation on arginine residues of histone and non-histone proteins, is overexpressed in many cancers.

JBI-778, a brain penetrant PRMT5 inhibitor demonstrated significant tumor growth inhibition in glioblastoma in addition to its activity against a number of other cancers - JBI-1527, a potent ...

PRMT5 catalyzes the formation of symmetrical dimethylarginine ... Addition of 1 μL of 0.5% (v/v) TFA was used to stop the methylation reaction at defined time points. One microliter of 6× concentrated ...