Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

This could explain why the p53 tumor suppressor gene and other elements of the DNA damage-response pathway are so often inactivated in cancer. Nevertheless, the role of DNA damage certainly hasn't ...

Co. Ltd. has received IND clearance from the FDA to initiate a phase I trial in the U.S. with NTS-071 for anticipated use in solid tumors with a p53 Y220C mutation. The trial is expected to begin in ...

Still, cancer is not an inevitable consequence of mutation, but is kept in check by intrinsic tumor-suppressor programs activated in damaged ... Modeling the therapeutic efficacy of p53 restoration in ...

Animation still showing the p53 tumour suppressor (yellow) protein binding to DNA (magenta/beige). p53 is a critical protein that determines how cells respond to DNA damage. Disclaimer ...

The influenza virus manipulates the body’s gene regulation system to accelerate its own spread, according to researchers at ...