Once researchers redefined p53 as a tumor suppressor gene and generated nonmutated clones, they began piecing together the puzzle of its role in the cell. One group showed that p53 controlled the ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Animation still showing the p53 tumour suppressor (yellow) protein binding to DNA (magenta/beige). p53 is a critical protein that determines how cells respond to DNA damage. Disclaimer ...

The work shows that the AGO2 protein follows the tumor suppressor p53 into the nucleus, binding itself to genes that regulate the body's alarm signals and turning them off. The researchers also ...

Co. Ltd. has received IND clearance from the FDA to initiate a phase I trial in the U.S. with NTS-071 for anticipated use in solid tumors with a p53 Y220C mutation. The trial is expected to begin in ...

Researchers looked at cells that had mutations in the Rb gene—a well-known tumor suppressor ... For instance, the combination of Rb and p53 loss caused tumors in fast-dividing neuroendocrine ...