Chromatin fractions enriched with certain histone modifications were captured by antibodies (H3K27me3 (CST, C36B11), H3K4me3 (Abcam, ab213224) and IgG) and released by protease digestion. RT-qPCR was ...

EZH2 is a histone methyltransferase. That means it places chemical marks on DNA-packaging proteins called histones. These marks can either silence or activate nearby genes. In healthy people ...

This important paper describes the regulatory pathway of rRNA synthesis by Meioc-Piwil1 in germ cell differentiation in zebrafish. Using the molecular genetic and cytological approaches, the authors ...

Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States Department of Pharmacological Sciences, Icahn School of Medicine at ...

State Key Laboratory of Tropical Oceanography, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou ...

Histone 3 trimethylation at lysine 36 (H3k36me3)—a chromatin signature induced by the histone methyltransferase SETD2 (SET domain containing 2)—correlates with changes in gene expression in human ...

and DNA molecules are coiled around the histone octamer to form the nucleosome’s core particles. DNA methylation is mediated by the enzyme DNA methyltransferase (DNMT), which transfers methyl groups ...

Loss of PRC2 at the repeat region corresponds with the binding of ASHL1, a histone lysine N-methyltransferase that is part of the TrixG group, which recruits DBE-T to chromatin. Thus, this lncRNA is ...