Single enzyme streamlines production of all four RNA building blocks

A single enzyme that can generate all four nucleoside triphosphates, the building blocks of ribonucleic acid (RNA), has been ...
eLife

Functionally coupled ion channels begin co-assembling at the start of their synthesis

BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.
eLife

Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
NPR

Guides to help you tackle your New Year's resolutions

Whatever your New Year's resolution looks like, NPR has a newsletter journey that will help you smash your goals this month. These limited-run newsletter series offer expert strategies and best ...