This study proposes a new mechanism by which Chd1 senses and responds to DNA unwrapping via EDBL engagement to suppress ...

Chromatin remodelers are ATP-dependent motor proteins that dynamically ... structures of yeast Chd1-nucleosome complexes in both ADP and stable ATP analogue ADP·BeF x-bound states, simulating ...

and by ATP-dependent protein complexes that physically remodel, move or remove nucleosomes. Chromatin structure is thought to regulate transcription factor access by modulating DNA accessibility.

Their study, published in Molecular Cell, highlights the role of a group of proteins called the PBAF chromatin remodeling complex in keeping melanoma from getting worse. Chromatin is the material ...

ATP-dependent chromatin remodeling complexes form several types of protein complexes, which reorganize chromatin structure cooperatively with histone modifiers. Williams syndrome transcription factor ...