News

BMJ1d
EULAR recommendations for the management of systemic lupus erythematosus: 2023 update
Correspondence to Dr Dimitrios T Boumpas, Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, "Attikon" University Hospital, Joint Academic Rheumatology Program, National ...
BMJ4d
Short-term dose and duration-dependent glucocorticoid risk for cardiovascular events in glucocorticoid-naive patients with rheumatoid arthritis
Objectives Rheumatoid arthritis (RA), along with glucocorticoid use, is associated with cardiovascular disease. Cardiovascular safety of glucocorticoids in RA is controversial and may be related to ...
BMJ1d
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications
Objective Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The ...
BMJ1d
Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis
Correspondence to Fenne Wouters, Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands; f.wouters{at}lumc.nl Objectives The human leukocyte antigen-shared ...
BMJ1d
AB0933 PHYSICAL ACTIVITY DECREASES PAIN AND INFLAMMATION IN GOUT PATIENTS
1 Rutgers Robert Wood Johnson Medical School, Medicine, New Brunswick, New Jersey, United States of America 2 The Ohio State University Wexner Medical Center, Medicine, Columbus, Ohio, United States ...
BMJ1d
Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis
Objectives Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties ...
BMJ5d
Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese
Correspondence to Dr Yukinori Okada, Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan; yokada{at}sg.med.osaka-u.ac.jp Objective Alteration of the ...
BMJ5d
Update οn the diagnosis and management of systemic lupus erythematosus
Clinical heterogeneity, unpredictable course and flares are characteristics of systemic lupus erythematosus (SLE). Although SLE is—by and large—a systemic disease, occasionally it can be ...
BMJ5d
Quantitative planar array screen of 1000 proteins uncovers novel urinary protein biomarkers of lupus nephritis
Objective The goal of these studies is to discover novel urinary biomarkers of lupus nephritis (LN). Methods Urine from systemic lupus erythematosus (SLE) patients was interrogated for 1000 proteins ...
BMJ1d
Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis
Objective Rheumatoid arthritis (RA) immunopathogenesis revolves around the presentation of poorly characterised self-peptides by human leucocyte antigen (HLA)-class II molecules on the surface of ...
BMJ5d
Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus
Objectives Systemic lupus erythematosus (SLE) is characterised by systemic inflammation involving various immune cell types. Monocytes, pivotal in promoting and regulating inflammation in SLE, ...
BMJ5d
Association of novel rare coding variants with juvenile idiopathic arthritis
Objective Juvenile idiopathic arthritis (JIA) is the most common type of arthritis among children, but a few studies have investigated the contribution of rare variants to JIA. In this study, we aimed ...