Northwestern Medicine scientists have uncovered how a testis-specific protein contributes to tumor growth and progression in ...

Scientists at the Icahn School of Medicine at Mount Sinai have made an exciting discovery about how human cells make RNA, a molecule that carries important instructions inside our bodies.

These insights from researchers could have major implications for diseases like cancer, where gene expression goes awry.

Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...

A new software algorithm developed at Caltech enables researchers to easily search for viruses in RNA sequence data, enabling ...

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...

This polymerase contains four catalytic subunits ... RNA pol I transcribes ribosomal RNAs (rRNAs), RNA pol II transcribes RNAs that will become messenger RNAs (mRNAs) and also small regulatory ...

The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

Lung cancer (LC) is a major global health issue, with high mortality rates and limited therapeutic options. It is primarily categorized into non-small cell lung cancer (NSCLC) and small cell lung ...

The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, Mediator, and RNA polymerase II (pol II). As a central integrator of both general and TF-specific regulatory signals, Mediator plays a ...

“It’s definitely a key advance in the field of understanding what RNA polymerase ribozymes can do, and it has pretty important implications for the RNA world theory,” he added. Study coauthors Gerald ...