Scientists have identified five specific blood proteins that can accurately predict a person's risk for developing a serious ...

Research in Mayo Clinic's Liver Disease Immunobiology Lab led by Petra Hirsova, Pharm.D., Ph.D., focuses on metabolic dysfunction-associated steatohepatitis.

While organoids aim to mimic human organs, the liver's repertoire of complex functions – and thus the energy it needs to operate – have made it challenging for researchers to grow organoids that ...

A more recent approach is transplantation of mature liver cells, known as hepatocytes. “The problem is obtaining sufficient quantities of fully functioning hepatocytes,” says Ochiya.

When the gene malfunctions, fat accumulates in liver cells and triggers inflammation. Over time, this leads to fibrosis and scarring, which stiffens the liver. In severe cases, the disease ...

In addition to the previous therapy with interferon-alpha, Hepcludex has recently become available as a drug that can effectively prevent HDV from entering liver cells. However, Hepcludex has no ...

Acute self-limiting and chronic liver injury are both associated with activation and proliferation of hepatic stellate cells (HSCs). In chronic injury, activated stellate cells are the major ...

Multi-modal data integration of single-nuclei RNA and ATAC sequencing with spatial transcriptomics, provides new molecular insights into gene regulatory networks driving cell state transitions in ...

The most common type is hepatocellular carcinoma, which begins in the main type of liver cell (hepatocyte). Other types of liver cancer, like intrahepatic cholangiocarcinoma and hepatoblastoma, are ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...