JSTOR Daily

Significance of Lyt Phenotypes: Lyt2 Antibodies Block Activities of T Cells That Recognize Class 1 Major Histocompatibility Complex Antigens Regardless of Their Function

The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of ...
EurekAlert!

A missing link in the MHC class divergence puzzle: Class II came first

Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...
Nature

Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps–SHP-2 pathway

The molecular mechanisms that fine-tune Toll-like receptor (TLR)-triggered innate inflammatory responses remain to be fully elucidated. Major histocompatibility complex (MHC) molecules can mediate ...
JSTOR Daily

Functional Evidence for the Mediation of Diabetogenic T Cell Responses by HLA-A2.1 MHC Class I Molecules through Transgenic Expression in NOD Mice

Particular major histocompatibility complex (MHC) class II alleles clearly contribute to T cell-mediated autoimmune type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice. However, ...
Nature

Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

Figure 1: MHC II-GFP expressed by dendritic cells exhibit properties characteristic of endogenous MHC II. As a further control, we found that the retroviral expression system—or expression of the ...
News Medical

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...