First discovered in the late 1990s, small-interfering RNA (siRNA) has been important within many applications in the post-genomic era. This article will discuss what siRNA is and the challenges ...

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases. However, siRNA drugs have challenges because siRNAs often ...

It is the first demonstration that multimeric siRNA molecules can be taken up into the lung after intranasal administration and achieve safe and robust genetic silencing. More importantly ...

Solving the side effect problem of siRNA drugs for genetic disease treatment using formamide Date: September 6, 2024 Source: Nagoya University Summary: Small interfering RNA (siRNA) drugs are a ...

Two start-ups have launched to develop next-generation drugs using small interfering RNA (siRNA) to silence genes. The first, Judo Bio, is a spin-off of the venture capital firm Atlas Venture.

NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP. Journal of Controlled Release , 2024; 373: 738 DOI: 10.1016/j.jconrel.2024.07.055 Cite This Page : ...

"This process inspired us to apply an analogous approach to the oligonucleotide platform's backbone—a small structural change making a big impact on siRNA's durability by increased stability and ...