The bacterial translation initiation mechanism uses only three initiation factors: IF1, IF2 and IF3 (ref. 1). In recent years, their functional analogs have been identified in eukaryotic cells; namely ...
eIF2B is Regulated via the Phosphorylation of its Substrate, eIF2 eIF2[αP] acts as a potent competitive inhibitor of eIF2B, thereby blocking the regeneration of active eIF2.GTP and the initiation of ...
Dephosphorylation of p-eIF2α requires enzymatic activity of PP1 phosphatase catalytic subunit, which is modulated by one of the two regulatory subunits, CReP or GADD34. CReP is expressed ...
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