When genes are coiled and compacted into chromatin, they're no longer accessible to transcription factors. So how does the cell know where to uncoil in a process called chromatin remodeling?

In eukaryotes, DNA is tightly wound into a complex called chromatin. Thanks to the process ... Recent evidence from the SWI/SNF and ISWI remodeler families has also revealed that remodeler ATPases ...

Scientists at the Icahn School of Medicine at Mount Sinai have discovered a possible reason why some cases of melanoma—a ...

Although mutations in the SWI/SNF remodeler subfamily are known to be linked to over 20% of all human cancers, how these mutations disrupt their interactions with DNA to ultimately lead to cancer ...

SMARCA4 and SMARCA2 are essential subunits of the SWI/SNF complex, functioning as ATP-dependent chromatin remodelers that regulate gene expression and maintain cellular homeostasis. Recent research ...