Signal-recognition particle (SRP)-dependent targeting of translating ribosomes to membranes is a multistep quality-control process. Ribosomes that are translating weakly hydrophobic signal sequences ...

The signal recognition particle (SRP) co-translationally targets proteins to the endoplasmic reticulum in eurkaryotes or to the plasma membrane in prokaryotes. As the initiating step, SRP binds to the ...

Trigger factor (TF) and signal recognition particle (SRP) bind to the bacterial ribosome and are both crosslinked to protein L23 at the peptide exit, where they interact with emerging nascent peptide ...

In order for newly-produced secretory or membrane proteins to find their final destination, the proteins have signal-sequences connected to themselves as a form of address tag. Furthermore, they use a ...

The signal recognition particle (SRP) recognizes polypeptide chains bearing a signal sequence as they emerge from the ribosome, and then binds its membrane-associated receptor (SR), thereby delivering ...

Researchers solve the more than 25-year-old puzzle of how proteins are sorted in the cell. A protein complex known as NAC (nascent polypeptide-associated complex) serves as a 'gatekeeper' in protein ...

For the maintenance of our cellular functions, it is essential that proteins are transported to various destinations within the cell – referred to as "cell organelles" in analogy to the organs of our ...

In order for newly-produced secretory or membrane proteins to find their final destination, the proteins have signal-sequences connected to themselves as a form of address tag. Furthermore, they use a ...

(Nanowerk News) In order for newly-produced secretory or membrane proteins to find their final destination, the proteins have signal-sequences connected to themselves as a form of address tag.