The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

The team, from biopharmaceutical company Regeneron, hopes their work will help researchers better understand protein-protein interactions during preclinical development of a drug. “Essentially, we ...

Researchers found a rare example of an ancient protein that can still function in a molecular mirror world – offering new clues about the evolutionary history of proteins that bind to nucleic acids.

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...

Hundreds of protein-ligand interactions have been identified through a collaboration between the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Pfizer. Georg ...

A new artificial intelligence model can predict how different proteins may bind to DNA. A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how ...

GPCRs (G-protein-coupled receptors) represent the largest family of membrane receptors currently targeted by approved drugs. It is estimated that approximately 700 approved drugs target GPCRs ...

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...