Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...
When proteins cause disease, the body has ways to tackle them. An emerging class of therapies that leverage a cell’s built-in systems to eliminate rogue proteins has already reached the clinic via ...
Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...
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