In our opinion, these SNPs may affect miRNA primary transcription and then expression of the mature miRNA. Finally, the ectopic expression of mature miRNAs may affect the translational suppression ...

In a recent study, researchers devised a strategy for genome-wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms ...

pri-miRNA: Primary miRNA; RISC: RNA-induced silencing complex; UTR: Untranslated region. Various gene silencing technologies like siRNA, miRNA, ribozymes, DNAzymes have shown promise as ...

pri-miRNA, primary miRNA; RISC, RNA-induced silencing complex; siRNA, small interfering RNA. The human genome predominantly encodes RNA molecules that do not translate into proteins, known as non ...

MicroRNA-27a has been shown to stimulate both the wingless-type integration site family, or Wnt signaling, and the bone morphogenetic protein pathways to actively promote bone regeneration, according ...

2012;9(5):549-559. However, since different proteins have different turnover times and miRNAs in most cases only cause modest decreases in protein translation, miRNA-mediated regulation of ...

Mirna's lead product candidate, MRX34, a mimic of naturally occurring microRNA-34 (miR-34), has been studied in a Phase 1 clinical trial which included patients with primary liver cancer ...

Phase II clinical study of radium-223 chloride (BAY 88-8223) in Japanese patients with symptomatic castration-resistant prostate cancer (CRPC) with bone metastases. This is an ASCO Meeting Abstract ...

They identified dickkopf-related protein 3 (DKK3) and sclerostin domain-containing protein 1 (SOSTDC1) as the primary target genes regulated by miRNA‑27a. In addition to DKK3 and SOSTDC1 ...