Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl) glycine ...

Svozil D; Sponer JE; Marchan I; Pérez A; Cheatham TE; Forti F; Luque FJ; Orozco M; Sponer J The anionic sugar-phosphate backbone of nucleic acids substantially contributes to their structural ...

In the few years since the introduction of peptide nucleic acid, or PNA (P.E. Ni et al., Science 254:1497-1500, 1991)-a nucleic acid analog with a peptide rather than sugar-phosphate backbone-no less ...

Xeno nucleic acids are essential for the development of nucleic acid-based drugs. To be effective, they need to be able to stably bind to natural RNA (a cellular single-stranded version of the DNA, ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

If you’ve ever learned a language, says Jen Heemstra of Emory University, there are two levels of understanding. First you learn to read text and comprehend it. Then you begin speaking the language ...

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Peptide nucleic acids (PNAs) are synthetic analogues of natural nucleic acids, distinguished by a peptide‐like backbone that confers unique binding affinities and high stability against enzymatic ...

As medical research progresses, traditional treatment protocols are being rapidly exhausted. New approaches to treat diseases that do not respond to conventional drugs are the need of the hour. In ...