News Medical

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

A new study published on the preprint server bioRxiv* analyzed the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of major histocompatibility ...
News Medical

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...
ascopubs.org

Melanoma-specific MHC-II expression to predict response to α-PD-1 therapy.

Patient-reported outcomes (PROs) in KEYNOTE-002, a randomized study of pembrolizumab vs chemotherapy in patients (pts) with ipilimumab-refractory (IPI-R) metastatic melanoma (MEL). This is an ASCO ...
ascopubs.org

Major histocompatibility complex class I (MHC 1) expression in clear cell renal cell carcinoma: Correlation with clinical outcome.

Assessment of time from cytoreductive nephrectomy (CN) to initiation of targeted therapy (TT) in patients with metastatic renal cell carcinoma (mRCC). This is an ASCO Meeting Abstract from the 2014 ...