Huntington’s Disease organoids (right) exhibit almost no neural progenitors (red) and also show defects in cellular polarity (yelllow). These defects have been described in the literature in human ...

Many neurological diseases are caused by pathogenic unstable intragenic trinucleotide repeat (TNR) expansions, such as the GAA trinucleotide repeat within the FXN gene in Friedreich ataxia (FRDA) and ...

Researchers have implicated a new gene in the progression of Huntington's disease in a brain organoid model. The gene may contribute to brain abnormalities much earlier than previously thought. Six ...