A catheter-based procedure that applies targeted ablation to the greater splanchnic nerve shows promise for improving exercise ability and biomarkers in patients with heart failure with preserved ...

AXON - percutaneous splanchnic nerve denervation. Presented at: THT 2022. New York, NY. The sham-controlled portion of the REBALANCE-HF trial has demonstrated that ablation of the greater splanchnic ...

Lately, however, the greater splanchnic nerves (GSN), which sympathetically control fluid redistribution to and from the abdomen, appear promising as a potential treatment target in heart failure.

In a series of 10 patients with HFpEF, surgical ablation of the right greater splanchnic nerve was followed by clinically meaningful improvements in cardiac filling pressures, exercise capacity ...