Leone et al. 2 recently reported that JHU083, an antagonist of glutamine metabolism, suppresses cancer-cell growth and stimulates antitumor T-cell function. Cancer cells take up glutamine ...

The scientists suggest that if the reversal of glutamine metabolism does not occur, the result may be blood diseases such as β-thalassemia. Detailed findings appeared in Science, in an article ...

The interest in glutamine metabolism has been heightened further by the recent findings that c-myc controls glutamine uptake and degradation, and that glutamine itself exerts influence over a ...

In particular, the work reveals that modulating glutamine metabolism is a potential therapeutic route for common red blood cell disorders. Additionally, glutamine abundance may serve as a tool for ...

Through conditional inactivation of the enzyme, the researchers identified a direct link between disruption of glutamine metabolism and red blood cell disorders. "We show this process is impaired ...

The paper is titled "Activation of the PGC-1α-mediated mitochondrial glutamine metabolism pathway attenuates female offspring osteoarthritis induced by prenatal excessive prednisone." The ...

For this reason, researchers are actively studying glutamine metabolism in the body to diagnose metabolic and degenerative diseases, including cancer treatment by inhibiting the metabolism of ...

“Individuals with variations in some genes related to glutamine metabolism may have a relatively greater predilection to develop cancer later,” says Ulm. “Some oncogenes — mutated genes ...

Some evidence suggests that it could affect metabolism in a way that increases the risk of metabolic syndrome, diabetes, and coronary artery disease. Experts say that even high doses of glutamine ...

PD-L1 expression and its prognostic value in metastatic papillary renal cell carcinoma: Results from a GETUG multicenter retrospective cohort. This is an ASCO Meeting Abstract from the 2024 ASCO ...