Many childhood cancers start with a hijacking at the molecular level. A group of abnormal proteins known as fusion proteins aberrantly engage with a collection of proteins that switches genes on and ...

Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with ...

Researchers have developed a new form of gene therapy that can stop cell division in fusion-driven cancer. A new study presents a promising treatment method for so-called fusion-driven cancers, which ...

A new paper published by researchers at Fox Chase Cancer Center highlights the case of a patient who was diagnosed with adenoid cystic carcinoma (ACC) after a molecular panel identified the presence ...

Using a novel bioinformatics approach, researchers identified a gene fusion that seems to occur in a majority of prostate cancers. A common feature of blood cancers, such fusions are rare in solid ...

Formation of fusion proteins. New genes are formed of two originally independent genes by chromosomal rearrangements, including translocations, insertions, deletions, duplications, and inversions.

Prevalence and Distribution of Unexpected Actionable Germline Pathogenic Variants Identified on Broad-Based Multigene Panel Testing Among Patients With Cancer The National Cancer Institute-Molecular ...

The FDA granted accelerated approval to the bispecific antibody zenocutuzumab (Bizengri) for NRG1 gene fusion-positive pancreatic adenocarcinoma and non-small cell lung cancer (NSCLC) on Wednesday.