Researchers have discovered that plant-derived phytochemicals and their gut microbiome metabolites control the effectiveness ...

Gut bacteria produce metabolites that influence drug metabolism and affect immune cell function, potentially enhancing or ...

First, cinnamon oil and cinnamic acid can activate receptors such as PXR and AhR, which regulate the production of liver enzymes responsible for drug metabolism, Church says. The activation of ...

Cytochrome P450 3A4 is an important mediator of drug catabolism that can be regulated by the steroid and xenobiotic receptor (SXR). We show here that SXR also regulates drug efflux by activating ...

"Understanding its bioaccessibility, metabolism and interaction with xenobiotic receptors was important to evaluate how excess intake of cinnamon would affect the prescription drugs if taken at ...

Pathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective ...

Could there be negative impacts from overconsumption of cinnamon products? People should be cautious because cinnamon could affect the metabolism of prescription drugs, according to a study published ...

Cases of drug-induced hemolytic anemia have also been described in patients treated with cyclosporine, tacrolimus, penicillin, and cefotetan. [14] The risk and severity of hemolysis are thought to ...

The study identified seasonal fluctuations in genes responsible for drug metabolism, particularly CYP2D6 and CYP2C19, which affect a quarter of common medications. Several widely used ...

A drug that restores brain metabolism in mouse models of Alzheimer's also improved cognitive function. The discovery could help researchers find additional pathways to combating the symptoms of ...