Since 2008, downstream purification issues have become progressively more acute problems for biomanufacturers. But that’s begun to change this year, according to results from BioPlan Associates’ 9th ...

Helping Downstream Processing To Follow Upstream Innovation. Complex biomolecules place unprecedented demands on conventional ...

Alternatives to Traditional Unit Operations Are Now Available to Alleviate Very Real Logjams Due to the complexity of therapeutic protein purification, downstream bioprocess bottlenecks can arise from ...

The two main fixation formats used by researchers are formalin fixation followed by paraffin embedding (FFPE) or snap-frozen in liquid nitrogen (referred to as Fresh Frozen or FF). There is less of a ...

Authors: Nick Koumakis and Rut Besseling. Protein aggregation in downstream processing (DSP) is a product-quality concern and major process-performance issue. Aggregate populations can reduce ...

Downstream processing encompasses the suite of separation, purification and formulation steps required to convert fermentation broths or other bioreactor outputs into high-purity bio-based chemicals.