As people age, their immune system function declines. T cell populations become smaller and can't react to pathogens as ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

New data highlight liver-encoded delivery of immune modulators as a strategy to mitigate age-related immune dysfunction.

As people age, their immune system function declines. T cell populations become smaller and can't react to pathogens as ...

Meet the Jekyll and Hyde of the immune system: activated CD8⁺ T cells. On June 24 in Nature Immunology, researchers led by Dorian McGavern at the National Institutes of Health introduce a granzyme ...

MIT and Broad Institute researchers have developed an mRNA approach that temporarily programs liver cells to produce ...

At the AD/PD meeting held last month in Vienna, scientists implicated T lymphocytes—specifically, the cytotoxic, CD8-positive variety—in Alzheimer’s disease. While the modus operandi of these cells in ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Metabolic reprogramming in the tumor microenvironment shapes immune function and therapy resistance, offering insights into ...