This important study builds on previous work from the same authors to present a conceptually distinct workflow for cryo-EM reconstruction that uses 2D template matching to enable high-resolution ...

Digital storage is an important element in any big data analysis project. In this blog we will look at some interesting biomedical big-data analysis applications for Quobyte’s software storage product ...

The cryogenic electron microscopy (cryo-EM) field exploded in popularity during the 2010s' "resolution revolution." The 2017 Nobel Prize in Chemistry awarded Jacques Dubochet, Joachim Frank, and ...

Cryo-EM is referred to as a form of EM where a transmission electron microscope (TEM) is used to obtain the image of radiation-sensitive specimens under cryogenic conditions. The phrase cryo-EM is ...

Structure-based designs facilitate drug discovery, and cryogenic electron microscopy (cryo-EM) is an increasingly important tool to determine high-resolution structures of proteins and protein ...

Getting a detailed look at human proteins is often key to designing drugs that target them. For decades, drug developers have typically relied on X-ray crystallography for that purpose—a technique ...

A technology called cryo-electron microscopy enables scientists to see the atomic structure of biological molecules in high resolution. But to date, it has been ineffective for imaging small molecules ...

Joël S. Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V. Filippova, Martina Niederer, Els Pardon, Jan Steyaert, Anthony A. Kossiakoff, Kaspar P. Locher ...