The most significant progress in this research field came with the demonstration that specific protein complexes involving cyclins ... suggested that regulation of the cell cycle is conserved ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Aa Aa Aa The cell cycle allows faithful inheritance of the genetic material from mother to daughter cells. Cell cycle events are controlled tightly by several kinase families including CDKs ...