Apellis Pharmaceuticals Inc. has identified C3 convertase inhibitors reported to be useful for the treatment of cancer, obesity, infections, neurological disorders, autoimmune and inflammatory ...

Serum complement proteins comprise an important system that is responsible for several innate and adaptive immune defence mechanisms. There were three well-described pathways known to lead to the ...

In all three pathways, C3-convertase cleaves and activates component C3, creating C3a and C3b, and causes a cascade of further cleavage and activation events. C3b binds to the surface of pathogens, ...

Panel A shows the profile of autoantibodies binding to factor B, C3b, and C3 activation fragments in Patients 1 and 2. I bars denote the standard deviation of three independent tests. As shown in ...

C3 glomerulopathies (C3G) are caused by dysregulation of the alternative complement pathway. In >50% of cases, these diseases are associated with expression of autoantibodies known as C3 nephritic ...