From the Department of Medicine, University of Chicago. Supported in part by a grant (AM-07091) from the United States Public Health Service. † Assistant professor of medicine, Department of ...

Conjugated hyperbilirubinemia occurs when bilirubin, a by-product of red blood cells, builds up in the blood. This can indicate several underlying causes, such as hepatitis, cirrhosis, or biliary ...

The metabolism of bilirubin begins with its production from heme in the spleen and bone marrow, followed by transportation to the liver, where it undergoes enzymatic conversion. The liver plays a ...

IN the development of new methods for detecting bilirubin in urine technical simplicity has generally been sacrificed for increased sensitivity and specificity. As a consequence many clinicians ...

Conjugation of bilirubin and delivery to the intestine doesn't necessarily lead to excretion of the substance. Neonatal intestines contain beta-glucuronidase, an enzyme capable of reducing ...