Bone marrow lesions (BMLs) are focal areas of altered signal intensity within the subchondral bone that emerge in the course of knee osteoarthritis. Detected most commonly by magnetic resonance ...

Chimeric antigen receptor-T cell (CAR-T cell) therapies have been a significant advance in the field of cancer immunotherapeutics in recent years, particularly for B-cell malignancies. Yet, this ...

Bone marrow adiposity refers to the presence and behaviour of fat cells within the marrow cavity, a compartment traditionally associated with blood production and bone turnover. Far from being inert, ...

In multiple myeloma, abnormal plasma cells build up inside bone marrow -- the spongy tissue inside large bones where blood cells are produced. Over time, myeloma cells cause damage to bones, kidneys, ...

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Myeloblasts are a type of immature white blood cell that form inside the bone marrow. Abnormal numbers of them can indicate serious health conditions. White blood cells are part of the immune system, ...

Up to a third of people worldwide have shoulder pain; it’s one of the most common musculoskeletal complaints. But medical imaging might not reveal the problem—in fact, it could even cloud it. In a ...

Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to quietly gain dominance with age. Reprogrammed stromal cells and interferon ...