Birmingham is a city in the north central region of Alabama, United States. It is the county seat of Jefferson County. The population was 200,73…Birmingham is a city in the north central region of Alabama, United States. It is the county seat of Jefferson County. The population was 200,733 at the 2020 census, making it the second-most populous city in Alabama, and estimated at 196,357 in 2024. The Birmingham metropolitan area had a population of 1.19 million in 2020 and is the largest metropolitan area in Alabama and 47th-most populous in the US. Birmingham serves as a major regional economic, medical, and educational hub of the Deep South, Piedmont, and Appalachian regions.