Cameron County is the southernmost county in the U.S. state of Texas. As of the 2020 census, its population was 421,017. Its county seat is Brownsville. The county was founded in 1848 and is named for Captain Ewen Cameron, a soldier during the Texas Revolution and in the ill-fated Mier Expedition. During the later 19th century and through World Wa…Cameron County is the southernmost county in the U.S. state of Texas. As of the 2020 census, its population was 421,017. Its county seat is Brownsville. The county was founded in 1848 and is named for Captain Ewen Cameron, a soldier during the Texas Revolution and in the ill-fated Mier Expedition. During the later 19th century and through World War II, Fort Brown was a US Army outpost here, stimulating the development of the city of Brownsville.